GLUT inhibitor
WZB 117 is a GLUT inhibitor (Ki(app) values are 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively). Competitive inhibitor of net glucose uptake but a noncompetitive inhibitor of sugar efflux from cells. Inhibits passive sugar transport in human erythrocytes and cancer cell lines. Attenuates erythrocyte 3-O-metylglucose (3MG) uptake
in vitro
(Ki = 6 μM). Suppresses tumor growth in a nude mouse model.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151127 |
| Réf. fabricant | 18786606 |
| Nom chimique ou matériau | 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate) |
| CAS | 1223397-11-2 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>20</sub>H<sub>13</sub>FO<sub>6</sub> |
| Poids de la formule | Observed MW: 368.31 |
