FTO inhibitor; anticonvulsant
MO-I-500 is a FTO inhibitor (IC50 = 8.7 μM for purified FTO
in vitro
), which increases N6-methyladenosine (m6A) levels in total cellular mRNA in HeLa cells. MO-I-500 modulates levels of specific miRNAs. In a triple-negative breast cancer cell line metabolically challenged by culture without glutamine (SUM149-MA cells), MO-I-500 inhibits cell proliferation. MO-I-500 also displays anticonvulsant activity in a 6 Hz mouse model of epilepsy at nontoxic doses.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151141 |
| Réf. fabricant | 18767216 |
| Nom chimique ou matériau | N-[5-(4-Chlorophenyl)-3,4-dihydroxy-2-furanyl]ethanesulfonamide |
| CAS | 1585219-04-0 |
| Quantité | 10 mg |
| Cible | Other Oxidase/Oxygenase Compounds |
| Formule moléculaire | C<sub>12</sub>H<sub>12</sub>ClNO<sub>5</sub>S |
| Pureté | 0.98 |
