Potent LMTK3 inhibitor
C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151188 |
| Réf. fabricant | 18747276 |
| Nom chimique ou matériau | 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine |
| Quantité | 10 mg |
| Cible | LMTK3 |
| Formule moléculaire | C<sub>18</sub>H<sub>11</sub>F<sub>3</sub>N<sub>4</sub>O |
| Pureté | 0.98 |
