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Tocris Bioscience™ CSN5i-3

Name: Tocris Bioscience™ CSN5i-3
Brand: Tocris Bioscience
SKU: 18709606
Price: 663.05 EUR
Availability: InStock

Réf. : BL-RE-151220Réf. fabricant : 18709606 2 mg

663,05 € HT

Potent and selective CSN5 (COP9 signalosome) inhibitor

Nom chimique ou matériau: 3-(Difluoromethyl)-N-(6-((5 S,6 S)-6-hydroxy-6,7,8,9-tetrahydro-5 H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1 H-pyrazole-5-carboxamide
CAS: 2375740-98-8
Quantité: 2 mg
Cible: Ubiquitin Ligase (E3) Inhibitors
Formule moléculaire: C₂₈H₂₉F₂N₅O₂
Marque: Tocris Bioscience

CSN5i-3 is a potent and selective CSN5 (COP9 signalosome) inhibitor. It inhibits deneddylation of NEDD8-modifed CRLs (IC50 = 5.8 nM), keeping them in the neddylated state, and leading to inactivation of a subset of CRLs by inducing degradation of their substrate receptor module (SRM). In A2780 ovarian cancer cells, CSN5i-3 down-regulates the expression of COPS5 and arrest cells at S-phase. In HUVECs

in vitro

and in zebrafish embryos

in vivo

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-151220
Réf. fabricant	18709606
Nom chimique ou matériau	3-(Difluoromethyl)-N-(6-((5 S,6 S)-6-hydroxy-6,7,8,9-tetrahydro-5 H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1 H-pyrazole-5-carboxamide
CAS	2375740-98-8
Quantité	2 mg
Cible	Ubiquitin Ligase (E3) Inhibitors
Formule moléculaire	C<sub>28</sub>H<sub>29</sub>F<sub>2</sub>N<sub>5</sub>O<sub>2</sub>
Pureté	0.98

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Tocris Bioscience™ CSN5i-3

Caractéristiques techniques

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