Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling
TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth
ex vivo
.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151224 |
| Réf. fabricant | 18705925 |
| Nom chimique ou matériau | 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide |
| CAS | 1008768-41-9 |
| Quantité | 50 mg |
| Cible | YAP1 |
| Formule moléculaire | C<sub>26</sub>H<sub>33</sub>N<sub>3</sub>O<sub>3</sub> |
| Pureté | 0.98 |
