NS 3728 is a volume-regulated anion channel (VRAC) blocker (IC50 = 460 nM). Blocks red blood cell chloride conductance (IC50 = 0.6 μM). NS 3728 also inhibits Ca2+-activated Cl- current (CaCC) by anoctamin (ANO) in an apparently voltage-dependent manner (IC50 against ANO1 = 2.1 and 0.7 μM at -95 and +50 mV, respectively).
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-151252 |
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| Réf. fabricant | 18709846 |
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| Nom chimique ou matériau | N-[3,5-bis(Trifluoromethyl)phenyl]-N'-[4-bromo-2-(2 H-tetrazol-5-yl)phenyl]urea |
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| CAS | 265646-85-3 |
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| Quantité | 10 mg |
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| Cible | Other Chloride Channel Blockers |
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| Formule moléculaire | C<sub>16</sub>H<sub>9</sub>BrF<sub>6</sub>N<sub>6</sub>O |
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| Pureté | 0.98 |
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