Selective AMPA receptor positive allosteric modulator
LY 404187 is a selective AMPA receptor positive allosteric modulator (IC50 values are 0.15, 0.21, 1.66 and 5.65 μM for GluA2i, GluA4i, GluA3i and GluA1i respectively). Potentiates glutamate and AMPA-evoked currents in pre frontal cortex (PFC) pyramidal neurons
in vitro
. Has no effect on NMDA- or kainate-evoked currents; also has no effect on K+ or Na+ ion channels. Potentiates PFC glutamatergic synaptic transmission
in vitro
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151269 |
| Réf. fabricant | 18750128 |
| Nom chimique ou matériau | N-[2-(4′-Cyano[1,1′-biphenyl]-4-yl)propyl]-2-propanesulfonamide |
| CAS | 211311-95-4 |
| Quantité | 50 mg |
| Cible | AMPA Receptor Modulators |
| Formule moléculaire | C<sub>19</sub>H<sub>22</sub>N<sub>2</sub>O<sub>2</sub>S |
| Poids de la formule | 342.46 |
| Pureté | >98% |
