TRPML channel activator
MK6-83 is a TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151272 |
| Réf. fabricant | 18703439 |
| Nom chimique ou matériau | MK6-83 |
| CAS | 1062271-24-2 |
| Synonyme | 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide |
| Quantité | 10 mg |
| Solubilité | Soluble to 100mM in DMSO and to 20mM in ethanol |
| Formule moléculaire | C<sub>1</sub><sub>6</sub>H<sub>2</sub><sub>0</sub>N<sub>2</sub>O<sub>2</sub>S<sub>2</sub> |
| Poids de la formule | 336.47 |
| Forme physique | Solid |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
