Viral RNA polymerase inhibitor
Favipiravir is a viral RNA polymerase inhibitor; exhibits no effects on mammalian RNA polymerase. Prodrug that is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5'-triphosphate (RTP). Reduces infection rate of SARS-CoV-2 in Vero E6 cells
in vitro
(IC50 = 61.88 μM). Inhibits influenza virus RNA-dependent RNA polymerase (RdRP) activity (IC50 = 341 nM). Induces lethal mutagenesis in MDCK cells inoculated with seasonal influenza A (H1N1) viruses. Protects mice against Ebola virus.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-151287 |
| Réf. fabricant | 18717116 |
| Nom chimique ou matériau | 6-Fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide |
| CAS | 259793-96-9 |
| Quantité | 50 mg |
| Cible | RNA/DNA Polymerase Inhibitors |
| Formule moléculaire | C<sub>5</sub>H<sub>4</sub>FN<sub>3</sub>O<sub>2</sub> |
| Pureté | 0.98 |
