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Tocris Bioscience™ SJFd

Name: Tocris Bioscience™ SJFd
Brand: Tocris Bioscience
SKU: 18065632
Price: 441.56 EUR
Availability: InStock

Réf. : BL-RE-151300Réf. fabricant : 18065632 5 mg

441,56 € HT

Potent and selective p38δ PROTAC™

Nom chimique ou matériau: N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,
CAS: 2254609-23-7
Quantité: 5 mg
Cible: Active Degraders
Formule moléculaire: C₆₂H₆₃F₂N₇O₁₂S
Marque: Tocris Bioscience

SJFδ is a potent and selective PROTAC ™ Degrader of p38δ (DC50 = 46.17 nM; Dmax = 99.41%). SJFδ comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Exhibits no significant degradation of p38α, β or γ. Selectively degrades p38δ in MDA-MB-231 cells.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-151300
Réf. fabricant	18065632
Nom chimique ou matériau	N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,
CAS	2254609-23-7
Quantité	5 mg
Cible	Active Degraders
Formule moléculaire	C<sub>62</sub>H<sub>63</sub>F<sub>2</sub>N<sub>7</sub>O<sub>12</sub>S
Pureté	98%

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Tocris Bioscience™ SJFd

Caractéristiques techniques

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