"/> Tocris Bioscience™ AZD 7648 | B-LABO France

Tocris Bioscience™ AZD 7648

Name: Tocris Bioscience™ AZD 7648
Brand: Tocris Bioscience
SKU: 18779796
Price: 203.02 EUR
Availability: InStock

Réf. : BL-RE-151400Réf. fabricant : 18779796 10 mg

203,02 € HT

Potent and selective DNA-PK inhibitor

Nom chimique ou matériau: 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
CAS: 2230820-11-6
Quantité: 10 mg
Cible: DNA-dependent Protein Kinase Inhibitors
Formule moléculaire: C₁₈H₂₀N₈O₂
Marque: Tocris Bioscience

AZD 7648 is a potent (IC50 = 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3Kα, PI3Kδ, PI3Kγ, ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable.

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-151400
Réf. fabricant	18779796
Nom chimique ou matériau	7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
CAS	2230820-11-6
Quantité	10 mg
Cible	DNA-dependent Protein Kinase Inhibitors
Formule moléculaire	C<sub>18</sub>H<sub>20</sub>N<sub>8</sub>O<sub>2</sub>

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Tocris Bioscience™ AZD 7648

Caractéristiques techniques

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