"/> Tocris Bioscience™ AZD 7648 | B-LABO France

Tocris Bioscience™ AZD 7648

Réf. : BL-RE-151401Réf. fabricant : 18799076 50 mg
786,16 € HT

Potent and selective DNA-PK inhibitor

Nom chimique ou matériau
7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
CAS
2230820-11-6
Quantité
50 mg
Cible
DNA-dependent Protein Kinase Inhibitors
Formule moléculaire
C18H20N8O2
Marque
Tocris Bioscience

AZD 7648 is a potent (IC50 = 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3Kα, PI3Kδ, PI3Kγ, ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-151401
Réf. fabricant18799076
Nom chimique ou matériau7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
CAS2230820-11-6
Quantité50 mg
CibleDNA-dependent Protein Kinase Inhibitors
Formule moléculaireC<sub>18</sub>H<sub>20</sub>N<sub>8</sub>O<sub>2</sub>
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