"/> Tocris™ SJF 8240 | B-LABO France

Tocris™ SJF 8240

Réf. : BL-RE-151432Réf. fabricant : 18797006 5 mg
323,97 € HT

c-MET PROTAC™; also degrades exon-14-deleted c-MET

Nom chimique ou matériau
N-(3-Fluoro-4-((7-(3-(3-(3-((-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic
CAS
2230821-68-6
Quantité
5 mg
Cible
Active Degraders
Formule moléculaire
C58H65F2N7O11S
Marque
Tocris

SJF 8240 is a c-MET PROTAC™Degrader. Comprises MET inhibitor foretinib (GSK 1363089; Cat. No. 6056) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours

in vitro

. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license

Caractéristiques techniques

MarqueTocris
Réf. B-LABOBL-RE-151432
Réf. fabricant18797006
Nom chimique ou matériauN-(3-Fluoro-4-((7-(3-(3-(3-((-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic
CAS2230821-68-6
Quantité5 mg
CibleActive Degraders
Formule moléculaireC<sub>58</sub>H<sub>65</sub>F<sub>2</sub>N<sub>7</sub>O<sub>11</sub>S
Pureté0.98
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