Inhibitor of group II p21 activated kinases
GNE 2861 is an inhibitor of group II p21 activated kinases (PAK; IC50 values are 7.5, 126 and 36 nM for PAK4, PAK5 and PAK6, respectively). Displays selectivity for group II PAK over a panel of 222 kinases. Inhibits tumor cell proliferation, migration and invasion in two breast cancer cell lines. Also sensitizes tamoxifen-resistant breast cancer cell lines to tamoxifen (Cat. No. 6342) via PAK4-dependent regulation of estrogen receptor α (ERα) target gene expression.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151437 |
| Réf. fabricant | 18709016 |
| Nom chimique ou matériau | 1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol |
| CAS | 1394121-05-1 |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>22</sub>H<sub>26</sub>N<sub>6</sub>O<sub>2</sub> |
| Poids de la formule | 406.48 |
| Pureté | 98% |
