Broad spectrum DUB inhibitor
PR 619 is a broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151442 |
| Réf. fabricant | 18712988 |
| Nom chimique ou matériau | PR 619 |
| CAS | 2645-32-1 |
| Synonyme | 2,6-Diamino-3,5-dithiocyanopyridine |
| Quantité | 10 mg |
| Solubilité | Soluble to 10mM in DMSO |
| Formule moléculaire | C<sub>7</sub>H<sub>5</sub>N<sub>5</sub>S<sub>2</sub> |
| Poids de la formule | 223.28 |
| Forme physique | Solid |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
