JW 74 is an inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3?/AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells
in vitro
. Inhibits tumor growth and formation in mouse models.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-151487 |
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| Réf. fabricant | 18727668 |
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| Nom chimique ou matériau | 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine |
|---|
| CAS | 863405-60-1 |
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| Quantité | 50 mg |
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| Solubilité | Soluble to 100mM in DMSO |
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| Formule moléculaire | C<sub>24</sub>H<sub>20</sub>N<sub>6</sub>O<sub>2</sub>S |
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| Poids de la formule | Observed MW: 456.52 |
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| Pureté | >99% |
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