NR 7h is a potent and selective p38α and p38β Degrader (PROTAC™) (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. NR 7h impairs replication of Mayaro virus in human dermal fibroblasts and HeLa cells. Active
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PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Caractéristiques techniques
| Marque | Tocris |
|---|
| Réf. B-LABO | BL-RE-151519 |
|---|
| Réf. fabricant | 18717546 |
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| Nom chimique ou matériau | 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2 H)-yl)-N-(4-(1-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)amino)-4-oxobutyl)-1 H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide |
|---|
| CAS | 2550399-06-7 |
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| Quantité | 5 mg |
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| Cible | Active Degraders |
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| Formule moléculaire | C<sub>48</sub>H<sub>50</sub>BrF<sub>2</sub>N<sub>9</sub>O<sub>8</sub> |
|---|
| Poids de la formule | 3636 |
|---|
| Pureté | 97% |
|---|
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