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Tocris Bioscience™ SJ 1008030

Name: Tocris Bioscience™ SJ 1008030
Brand: Tocris Bioscience
SKU: 18738166
Price: 242.97 EUR
Availability: InStock

Réf. : BL-RE-151535Réf. fabricant : 18738166 2 mg

242,97 € HT

Selective JAK2 Degrader (PROTAC™)

Nom chimique ou matériau: 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1 H-pyrazol-4-yl)-7 H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide trifluoroacetate
Quantité: 2 mg
Cible: Active Degraders
Formule moléculaire: C₄₂H₄₃N₁₃O₇S.CF₃CO₂H
Pureté: 0.98
Marque: Tocris Bioscience

SJ 1008030 is a potent and selective JAK2 Degrader (PROTAC®). This compound shows potent antileukemic efficacy in CRLF2r ALL (Acute Lymphoblastic Leukemia) cell lines (EC50 = 5.4 nM). SJ 1008030 induces dose-dependent JAK2 degradation (IC50 = 32.05 nM) in xenograft models of kinase-driven ALL, with no effect on GSPT1 levels.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-151535
Réf. fabricant	18738166
Nom chimique ou matériau	4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1 H-pyrazol-4-yl)-7 H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide trifluoroacetate
Quantité	2 mg
Cible	Active Degraders
Formule moléculaire	C<sub>42</sub>H<sub>43</sub>N<sub>13</sub>O<sub>7</sub>S.CF<sub>3</sub>CO<sub>2</sub>H
Pureté	0.98

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Tocris Bioscience™ SJ 1008030

Caractéristiques techniques

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