"/> Tocris Bioscience™ PDD 00017273 | B-LABO France

Tocris Bioscience™ PDD 00017273

Réf. : BL-RE-151550Réf. fabricant : 18749356 10 mg · White
404,96 € HT

Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeable

Nom chimique ou matériau
1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
CAS
1945950-21-9
Quantité
10 mg
Solubilité
Soluble to 100mM in water and to 100mM in DMSO
Cible
PARG Inhibitors
Marque
Tocris Bioscience

PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1

BRCA1

WT cells and inhibits cancer cell survival. Cell permeable.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-151550
Réf. fabricant18749356
Nom chimique ou matériau1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
CAS1945950-21-9
Quantité10 mg
SolubilitéSoluble to 100mM in water and to 100mM in DMSO
CiblePARG Inhibitors
Formule moléculaireC<sub>23</sub>H<sub>26</sub>N<sub>6</sub>O<sub>4</sub>S<sub>2</sub>
Poids de la formule514.62
Forme physiqueSolid
CouleurWhite
Type de produitBioactive Small Molecule
Pureté>98%
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