MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA-MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In
ex vivo
muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth.
Caractéristiques techniques
| Marque | Tocris Bioscience |
|---|
| Réf. B-LABO | BL-RE-151569 |
|---|
| Réf. fabricant | 18024672 |
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| Nom chimique ou matériau | 4-[[4-(Diethylamino)phenyl]amino]-6-methyl-3-quinolinecarboxylic acid ethyl ester |
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| CAS | 371924-24-2 |
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| Quantité | 50 mg |
|---|
| Cible | Mitochondrial Calcium Uniporter Inhibitors |
|---|
| Formule moléculaire | C<sub>23</sub>H<sub>27</sub>N<sub>3</sub>O<sub>2</sub> |
|---|
| Pureté | 98% |
|---|
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