Potent LRRK2 inhibitor
CZC 25146 is a potent LRRK2 inhibitor (IC50 values are 4.76 and 6.87 nM for for wild-type and G2019S mutant forms of LRRK2, respectively). Also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2. Attenuates mutant LRRK2-induced injury of cultured rodent and human neurons. Cell permeable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151651 |
| Réf. fabricant | 18729807 |
| Nom chimique ou matériau | CZC 25146 |
| CAS | 1191911-26-8 |
| Synonyme | N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide |
| Quantité | 50 mg |
| Solubilité | Soluble to 100mM in DMSO |
| Formule moléculaire | C<sub>22</sub>H<sub>25</sub>FN<sub>6</sub>O<sub>4</sub>S |
| Poids de la formule | 488.54 |
| Forme physique | Solid |
| Couleur | Pale-purple |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
