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STEMCELL Technologies Verteporfin | B-LABO France
STEMCELL Technologies Verteporfin
Réf. : BL-RE-151700Réf. fabricant : 17159981 1 mg
48,60 € HT
YAP1 inhibitor
CAS
129497-78-5
Synonyme
BPD-MA; CL 318,952
Quantité
1 mg
Formule moléculaire
C41H42N4O8
Pureté
≥95%
Marque
STEMCELL Technologies
Caractéristiques principales
Verteporfin is a benzoporphyrin derivative that inhibits autophagosome formation by directly targeting and modifying p62, a scaffold protein that targets polyubiquitinated proteins for degradation (Donohue et al.) Verteporfin also disrupts YAP-TEAD interactions by enhancing trypsin cleavage of YAP (EC50 = 100 nM; Brodowska et al.; Liu-Chittenden et al.)
Inhibits the growth, proliferation, and viability of human retinoblastoma cells (Brodowska et al.)
Inhibits self-renewal in cancer stem cells with high YAP1 and ALDH1 levels (Song et al.)
