Torin 2 is a potent and selective ATP-competitive inhibitor against mTOR (EC50 = 0.25 nM), a key regulator of cell growth, survival, and autophagy (Liu et al.; Petherick et al.)
Inhibits proliferation of lung, breast, colorectal, and cervical cancer cell lines (Liu et al.)
Blocks mTOR complex 1 (mTORC1)-associated cell cycle progression and induces autophagy in hepatocellular carcinoma cells (Wang et al.)
