AM580 is a retinoic acid receptor (RAR) agonist that is selective for RARα (EC50 = 0.36 nM) compared to RARβ (EC50 = 24.6 nM) and RARγ (EC50 = 27.9 nM; Bernard et al.) It is a derivative of retinoic acid (RA), however it demonstrates greater specific binding to RARα compared to RA, which exhibits little selectivity across RARα, β, or γ (Gianní et al.; Bernard et al.; Kim et al; Rochette-Egly & Germain)
Promotes reprogramming of somatic cells to induced pluripotent stem cells (Wang et al.)
Induces differentiation of human induced pluripotent stem cells into intermediate mesoderm, in combination with the GSK3β inhibitor CHIR99021 (Araoka et al.)
Inhibits tumor cell proliferation and survival signaling pathways, and induces apoptosis, leading to inhibition of mouse mammary tumor virus (MMTV)-neu- and MMTV-wnt1-induced mammary gland hyperplasia (Lu et al.)
Inhibits tumor growth in MMTV-Myc mice (Bosch et al.)
Inhibits endometrial cancer cell proliferation (Cheng et al.)
Induces differentiation in acute promyelocytic leukemia cells (Gianní et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-151717
Réf. fabricant
17150152
CAS
102121-60-8
Synonyme
CD336; NSC 608001; Ro 40-6055
Quantité
10 mg
Formule moléculaire
C<sub>22</sub>H<sub>25</sub>NO<sub>3</sub>
Pureté
≥98%
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