8-Bromo-cAMP is a membrane-permeable cAMP derivative
It can activate cAMP-dependent protein kinase, with long-acting effects due to its resistance to cAMP phosphodiesterase (Schwede et al.) It can be used to study calcium-mediated pathways (IC50 = 0.84 mM; Xaus et al.) REPROGRAMMING
Improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells, in combination with vaLproic acid (Wang & Adjaye)
Inhibits M-CSF-dependent proliferation of macrophages (Xaus et al.)
Protects neutrophils against TNF-α-induced apoptosis (Krakstad)
Induces a proliferative response in an IL-3-dependent leukemic cell line (Barge et al.)
Induces membrane depolarization in pancreatic cancer cell lines (Sorio et al.)
