PluriSIn-1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (Ben-David et al.)
Selectively eliminates undifferentiated human embryonic stem (ES) and induced pluripotent stem (iPS) cells while sparing differentiated cells, and prevents teratoma formation in transplanted mice (Ben-David et al.)
Induces apoptosis of Nanog-positive iPS cells in vitro, while leaving iPS cell-derived cardiomyocytes unaffected (Zhang et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-151755
Réf. fabricant
17140132
CAS
91396-88-2
Synonyme
N’-phenyl-hydrazine-Isonicotinic acid; NSC 14613
Quantité
50 mg
Formule moléculaire
C<sub>12</sub>H<sub>11</sub>N<sub>3</sub>O
Pureté
≥95%
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