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STEMCELL Technologies Doxycycline (Hyclate) | B-LABO France
STEMCELL Technologies Doxycycline (Hyclate)
Réf. : BL-RE-151762Réf. fabricant : 17100122 1 g
97,20 € HT
Antibiotic; Used in Tet-inducible gene expression systems
CAS
24390-14-5
Synonyme
WC 2031
Quantité
1 g
Formule moléculaire
2[C22H24N2O8] · 2HCl · H2O · C2H6O
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
Doxycycline is a tetracycline-like antibiotic (Hicks et al.; Nau et al.; Solís García del Pozo & Solera; Steinhardt et al.) In genetic engineering, doxycycline is used as the regulator for inducible gene expression systems, whereby expression depends on either the presence (Tet-On) or absence (Tet-Off ) of doxycycline
Also, doxycycline inhibits certain matrix metalloproteinases (MMP), such as MMP-8 (Ki = 36 μM; Griffin et al.; Smith et al.) It only poorly inhibits MMP-1 and MMP-13 (Ki > 100 μM; Smith et al.) This product is supplied as the hyclate salt of the molecule
Used as the regulator for inducible gene expression in lentiviral infection and transgenic mouse models using the Tet-On or Tet-Off systems (Brambrink et al.; Carey et al.; Haenebalcke et al.; Hanna et al.; Hockemeyer et al.; Maherali et al.; Markoulaki et al.; Stadtfeld et al. 2008, 2010; Wernig et al.)
