JIB-04 is an epigenetic modifier that is a pan-selective inhibitor of Jumonji histone demethylase enzymes
It inhibits members of the family in the high nanomolar range with IC50 values of 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3, and JMJD2C, respectively
It shows no activity against histone deacetylases and minimal effects against iron-containing enzymes methylcytosine dioxygenase TET1 and prolyl hydroxylases (Wang et al.; Easmon et al.)
Inhibits proliferation in a variety of human tumor cell lines (Easmon et al.)
Selectively toxic to lung or prostate cancer cells in vitro, and not to normal cells of the same cell type or to normal control lines isolated from the same patient (Wang et al.)
Reduces tumor burden and prolongs survival in a mouse model of breast cancer (Wang et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-151764
Réf. fabricant
17100192
CAS
199596-05-9
Synonyme
JHDM Inhibitor VII; NSC 693627
Quantité
10 mg
Formule moléculaire
C<sub>17</sub>H<sub>13</sub>ClN<sub>4</sub>
Pureté
≥95%
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