Cyclopamine is a steroid alkaloid that inhibits the Hedgehog pathway at the point of the pathway activator Smoothened
Cyclopamine binds to the heptahelical bundle of Smoothened, a G protein-coupled receptor, and prevents it from signaling further downstream (Chen et al.)
Reduces proliferation of rat neural progenitor cells and mouse neurospheres (Lai et al.; Palma and Ruiz i Altaba)
Reduces proliferation of mouse mammospheres (Liu et al.)
Promotes differentiation of pancreatic cells from human embryonic stem cells (D'Amour et al.)
Inhibits the growth of human and mouse medulloblastoma cells, and human glioblastoma cells (Bar et al.), Berman et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-151774
Réf. fabricant
17130022
CAS
4449-51-8
Synonyme
11-Deoxojervine; Jervine
Quantité
5 mg
Formule moléculaire
C<sub>27</sub>H<sub>41</sub>NO<sub>2</sub>
Pureté
≥95%
Une question, une configuration particulière ? Contactez-nous pour un devis.
