DBZ is a diazepine inhibitor of γ-secretase, which cleaves transmembrane proteins including Notch, amyloid precursor protein (APP), and Ephrin-B2 (Borgegard et al)
DBZ blocks the cleavage of Notch into its active signalling effector, Notch intracellular domain, with an IC50 of 1.7 nM (Milano et al.)
