Potent pan-Raf kinase inhibitor
LY 3009120 is a potent pan-Raf kinase inhibitor (IC50 values are 31 - 47, 42 and 44 nM for b-RAF, c-RAF and a-RAF in A375 cells, respectively). Also inhibits kinase activity of Raf hetero- and homodimers. Displays antiproliferative effects against b-RAF and Ras mutant melanoma cells. Inhibits MEK and ERK phosphorylation, and b-RAF and Ras mutant tumor growth in mouse xenograft models.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-151787 |
| Réf. fabricant | 18747436 |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>23</sub>H<sub>29</sub>FN<sub>6</sub>O |
| Poids de la formule | 424.52 |
| Type de produit | Inhibitor |
| Pureté | 98% |
