Dihydrochloride salt of SAG; Smo receptor agonist
SAG dihydrochloride is a water-soluble dihydrochloride salt of SAG (Cat. No. 4366). SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ∼ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-157975 |
| Réf. fabricant | 18053842 |
| Nom chimique ou matériau | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride |
| CAS | 2702366-44-5 |
| Plage de pourcentage du dosage | >99% |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>28</sub>H<sub>28</sub>ClN<sub>3</sub>OS0.2 HCl |
| Poids de la formule | Observed MW: 562.98 |
| Pureté | 98% |
