Potent UNC-51-like kinase 1 (ULK1) agonist
LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC50 = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC50 = 1.66 μM) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-158001 |
| Réf. fabricant | 18747706 |
| Nom chimique ou matériau | 2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride |
| CAS | 2310109-38-5 |
| Quantité | 10 mg |
| Cible | ULK1 |
| Formule moléculaire | C<sub>33</sub>H<sub>43</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>2</sub>.2HCl |
