Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-158009 |
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| Réf. fabricant | 18746736 |
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| Nom chimique ou matériau | Echinomycin |
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| CAS | 512-64-1 |
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| Synonyme | N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether |
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| Quantité | 1 mg |
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| Solubilité | Soluble to 5mM in DMSO |
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| Formule moléculaire | C<sub>5</sub><sub>1</sub>H<sub>6</sub><sub>4</sub>N<sub>1</sub><sub>2</sub>O<sub>1</sub><sub>2</sub>S<sub>2</sub> |
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| Poids de la formule | 1101.26 |
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| Forme physique | Solid |
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| Type de produit | Bioactive Small Molecule |
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| Pureté | >98% |
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