Potent, irreversible FGFR inhibitor
FIIN 1 hydrochloride is a potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-158046 |
| Réf. fabricant | 18005452 |
| Nom chimique ou matériau | N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide |
| CAS | 1256152-35-8 |
| Quantité | 2 mg |
| Cible | FGF Receptor Inhibitors |
| Formule moléculaire | C<sub>32</sub>H<sub>39</sub>Cl<sub>2</sub>N<sub>7</sub>O<sub>4</sub> |
| Pureté | 96% |
