Potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR); attenuates proliferation of CD4+ T cells
SPRi 3 is a potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Suppresses proliferation of human effector CD4+ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC50 = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells
in vivo
. Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-158102 |
| Réf. fabricant | 18769876 |
| Nom chimique ou matériau | N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide |
| CAS | 1292285-54-1 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>14</sub>H<sub>18</sub>N<sub>2</sub>O<sub>3</sub> |
| Poids de la formule | 262.3 |
| Pureté | 98% |
