PB 28 dihydrochloride is a high affinity σ2 receptor agonist (Ki values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-158119 |
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| Réf. fabricant | 18742694 |
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| Nom chimique ou matériau | 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride |
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| CAS | 172907-03-8 |
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| Plage de pourcentage du dosage | >99% |
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| Quantité | 50 mg |
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| Solubilité | Soluble to 20mM with gentle warming in water |
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| Formule moléculaire | C<sub>24</sub>H<sub>38</sub>N<sub>2</sub>O.2HCl |
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| Poids de la formule | Observed MW: 443.5 |
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