MTK 458 is a brain penetrant PTEN-induced kinase 1 (PINK1) activator. It binds to and stabilizes the active form of PINK1, increasing its activity and activating mitophagy downstream. It mediates clearance of pathogenic α-synuclein and normalizes pS65-Ubiquitin (pUb) in
in vivo
Parkinson's models. MTK458 is orally bioavailable.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-158128 |
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| Réf. fabricant | 18044812 |
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| Nom chimique ou matériau | N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
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| CAS | 2499962-58-0 |
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| Quantité | 10 mg |
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| Cible | PINK1 |
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| Formule moléculaire | C<sub>17</sub>H<sub>15</sub>F<sub>3</sub>N<sub>4</sub> |
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| Pureté | 0.98 |
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