"/> Tocris Bioscience™ CST 905 | B-LABO France

Tocris Bioscience™ CST 905

Name: Tocris Bioscience™ CST 905
Brand: Tocris Bioscience
SKU: 18056062
Price: 343.07 EUR
Availability: InStock

Réf. : BL-RE-158132Réf. fabricant : 18056062 5 mg

343,07 € HT

Potent and selective BRAFV600E Degrader (PROTAC™)

Nom chimique ou matériau: (2S,4R)-1-((S)-2-(2-(4-(4-(3-(3-((N-Ethyl-N-methylsulfamoyl)amino)-2,6-difluorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantité: 5 mg
Cible: Active Degraders
Formule moléculaire: C₅₁H₅₈F₂N₁₀O₇S₂
Pureté: 98%
Marque: Tocris Bioscience

CST 905 is a potent and selective BRAFV600E Degrader (PROTAC™) (DC50 = 18 nM). CST 905 comprises a ligand for the von Hippel Lindau (VHL) E3 ligase joined by a linker to a PLX-derived ligand. Unlike other BRAFV600E Degraders, CST 905 does not activate ERK. B-Raf antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF3424 .

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-158132
Réf. fabricant	18056062
Nom chimique ou matériau	(2S,4R)-1-((S)-2-(2-(4-(4-(3-(3-((N-Ethyl-N-methylsulfamoyl)amino)-2,6-difluorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantité	5 mg
Cible	Active Degraders
Formule moléculaire	C<sub>51</sub>H<sub>58</sub>F<sub>2</sub>N<sub>10</sub>O<sub>7</sub>S<sub>2</sub>
Pureté	98%

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Tocris Bioscience™ CST 905

Caractéristiques techniques

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