Highly potent and selective CB2 inverse agonist
SCH 336 is a highly potent and selective CB2 receptor inverse agonist (Ki = 1.8 nM, EC50 = 2 nM). Displays 100-fold selectivity for CB2 receptors over CB1. Increases forskolin stimulated cAMP accumulation in CHO cells expressing human CB2 receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-158147 |
| Réf. fabricant | 18783998 |
| Nom chimique ou matériau | N-[(1S)-1-[4-[[4-Methoxy-2-[(4-methoxyphenyl)sulfonyl]phenyl]sulfonyl]phenyl]ethyl]methanesulfonamide |
| CAS | 447459-51-0 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>23</sub>H<sub>25</sub>NO<sub>8</sub>S<sub>3</sub> |
| Poids de la formule | Observed MW: 539.64 |
