SSYA10-001 is a potent coronavirus helicase inhibitor (IC50 values are 0.046 μM and >3 μM for unwinding and ATPase, respectively). Inhibits SARS-CoV-2 Nsp13 helicase (IC50 = 3.5 μM), blocks dsDNA and dsRNA unwinding activities of Nsp13 (IC50 values are 5.3 μM and 5.7 μM respectively). In a SARS-CoV replicon assay SSYA10-001 inhibits (+) sense but not (-) sense RNA synthesis (EC50 = 8.95 μM). Also inhibits human papillomavirus E6 (IC50 = 10 μM)
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-158173 |
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| Réf. fabricant | 18716586 |
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| Nom chimique ou matériau | 2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3 H-1,2,4-triazole-3-thione |
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| CAS | 675104-49-1 |
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| Quantité | 10 mg |
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| Cible | Antiviral Compounds |
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| Formule moléculaire | C<sub>12</sub>H<sub>12</sub>N<sub>4</sub>O<sub>2</sub>S<sub>2</sub> |
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| Pureté | 0.98 |
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