Potent and selective allosteric activator of AMPK
PF 06409577 is a potent and selective allosteric activator of AMPK (EC50 values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Exhibits minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Improves kidney function and reduces proteinuria in a preclinical model of diabetic nephropathy. Orally bioavailable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-158182 |
| Réf. fabricant | 18756559 |
| Nom chimique ou matériau | PF 06409577 |
| CAS | 1467057-23-3 |
| Synonyme | 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid |
| Quantité | 50 mg |
| Solubilité | Soluble to 100mM in DMSO and to 20mM in ethanol |
| Formule moléculaire | C<sub>19</sub>H<sub>16</sub>ClNO<sub>3</sub> |
| Poids de la formule | 341.79 |
| Forme physique | Solid |
| Couleur | Gray |
| Type de produit | Bioactive Small Molecule |
| Pureté | 99% |
