Potent and selective RXR agonist
Bexarotene is a potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration
in vitro
, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-158199 |
| Réf. fabricant | 18731348 |
| Nom chimique ou matériau | 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid |
| CAS | 153559-49-0 |
| Synonyme | LGD 1069 |
| Quantité | 10 mg |
| Cible | Retinoid X Receptor Agonists |
| Formule moléculaire | C<sub>24</sub>H<sub>28</sub>O<sub>2</sub> |
| Poids de la formule | 348.48 |
| Pureté | >99% |
