Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation
PIK 90 is a potent inhibitor of PI 3-K α/γ/δ kinases (IC50 = 11, 18, 47, 58 and 64 nM against p110α, p110γ, PI 3-KC2α, p110δ and PI 3-KC2α, respectively) as well as PIKKs (IC50 = 13 nM against DNA-PK). It inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells. It suppresses insulin-stimulated phosphorylation of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes
in vitro
and prevents insulin-induced blood glucose reduction in mice
in vivo
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-158205 |
| Réf. fabricant | 30000011 |
| Nom chimique ou matériau | N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide |
| CAS | 677338-12-4 |
| Quantité | 10 mg |
| Cible | PI 3-Kinase Inhibitors |
| Formule moléculaire | C<sub>18</sub>H<sub>17</sub>N<sub>5</sub>O<sub>3</sub> |
| Pureté | 0.98 |
