WNT pathway activator; Inhibits protein phosphatase PP2A
CAS
331001-62-8
Quantité
25 mg
Formule moléculaire
C21H22N4O2
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
IQ-1 selectively inhibits p300-dependent β-catenin signaling by binding to the PR72/130 subunit of protein phosphatase PP2A, leading to decreased phosphorylation of the β-catenin coactivator, p300, and decreased affinity of p300 for β-catenin
IQ-1 thereby inhibits β-catenin/p300 interaction while increasing β-catenin/CBP mediated transcription (Miyabayashi et al.)
Used with Wnt3a to maintain pluripotency of mouse embryonic stem (ES) cells in the absence of mouse embryonic fibroblasts (MEFs), serum, or exogenous leukemia inhibitory factor (LIF; Miyabayashi et al.)
Enhances expansion of mouse ES-derived cardiovascular progenitor cells (Schenke-Layland et al.)
Induces the conversion of cancer cells to a side population of cancer stem-like cells with high levels of drug resistance and tumorigenicity (He et al.)
