Réf. : BL-RE-158315Réf. fabricant : 18476608 50 mL
Prix sur devis
Tarif personnalisé selon la configuration et la quantité.
POROS™ CaptureSelect™ AAV8 high performance affinity resin is engineered to address the high selectivity and capacity requirements needed for the purification of viral vectors used for gene therapy applications and is specifically intended for the purification of adeno-associated virus type 8 (AAV8).
Features of POROS CaptureSelect AAV8 resin include:
POROS CaptureSelect AAV8 affinity resin specifically binds AAV8 and enables a robust, fast, and efficient purification process with excellent purity and yield obtained in one step. The use of this affinity resin will enable significant improvement to downstream processing by reducing the purification steps and maximizing productivity, for scalability and processing consistency.
Points forts
Main characteristics
Matrix: cross-linked poly(styrene-divinylbenzene)
Average particle size: 50 μm
Ligand: CaptureSelect AAV8 affinity ligand
Ligand coupling method: carbonyldiimidazole (CDI)
Binding capacity: >1x1013 genome copies/mL of resin
Elution conditions: acidic elution with 0.1 M glycine, pH 3.0
Caractéristiques principales
One-step AAV8 purification from crude material with high purity and yield
High specificity and capacity, which helps reduce the process volume significantly for subsequent steps and maximizes yield
Low operating back pressure and linear pressure versus flow responses driving flexible scalability
Superior capacity maintained at high flow rates
Rigid polymeric bead with covalent surface chemistry for easier handling and packing, with superior physical and chemical stability enabling a more robust downstream purification process
Non-animal derived—the ligand is a 13-kDa single-domain fragment that comprises the 3 CDRs that form the antigen-binding domain and is efficiently produced by the yeast Saccharomyces cerevisiae in a production process free of animal components.
Caractéristiques techniques
Marque
Thermo Scientific
Réf. B-LABO
BL-RE-158315
Réf. fabricant
18476608
Capacité de liaison
>1 x 10<sup>13</sup> genome copies/mL of resin
Matrice
Cross-linked poly(styrene-divinylbenzene)
Contenu et stockage
Store at 2°C to 8°C.
Conditions d’expédition
Wet Ice
Granulométrie
50 μm
Forme
Liquid Suspension
Gamme de produits
CaptureSelect™, POROS™
Quantité
50 mL
Type
Resin
Type de ligand
AAV8 affinity ligand
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