Potent cathepsin C inhibitor
AZD 5248 is a potent cathepsin C (also known as dipeptidyl peptidase 1, or DPP1) inhibitor (IC50 values are 44 and 67 nM for human and rat, respectively).
In vivo
, AZD 5248 inhibition of cathepsin C correlates to the reduction of NSP (neutrophil serine protease) activity measured in rat bone marrow and blood. In rats, quantitative whole-body autoradiography studies demonstrate aortic binding of AZ 5248. This compound is orally bioavailable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-160708 |
| Réf. fabricant | 18735766 |
| Nom chimique ou matériau | 4-Amino-N-[(1S)-1-cyano-2-(4'-cyano[1,1'-biphenyl]-4-yl)ethyl]tetrahydro-2H-pyran-4-carboxamide |
| CAS | 1254318-44-9 |
| Quantité | 1 mg |
| Cible | Synthetic Cathepsin Inhibitors |
| Formule moléculaire | C<sub>22</sub>H<sub>22</sub>N<sub>4</sub>O<sub>2</sub> |
| Pureté | 0.98 |
