PEGylated DSPE with a maleimide reactive group
DSPE-PEG (2000) maleimide is a functionalized phospholipid-polymer conjugate. It comprises a 1,2-distearoyl-sn-glycero-PE (DSPE) covalently coupled to a linear polyethylene glycol (
M
r 2000) with a maleimide-terminated end. It is used to synthesize antibody-coupled PEG (2000)-DSPE micelles that can be transferred into liposomes to generate immunoliposomes. DSPE-PEG (2000) maleimide can also be incorporated into the outer membrane of lipid nanoparticles (LNPs) for further bioconjugation. It is used in antibody-targeted LNP-mRNA systems to generate transient antifibrotic chimeric antigen receptor (CAR) T cells
in vivo
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-160731 |
| Réf. fabricant | 30000436 |
| Nom chimique ou matériau | 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol-2000)] |
| Quantité | 10 mg |
| Cible | Lipid Nanoparticles |
| Formule moléculaire | (C<sub>2</sub>H<sub>4</sub>O)<sub>n</sub>C<sub>51</sub>H<sub>91</sub>N<sub>3</sub>O<sub>13</sub>P.NH<sub>4</sub> or Na |
| Pureté | 90% |
