Piezo1 channel activator
Yoda 1 is a selective activator of mouse and human mechanosensitive channel piezo1. In HEK cells, Yoda 1 slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure. In MDCK cells, Yoda 1 induces Ca2+-dependent chromatin hypercondensation and alters Ca2+-dependent myosin contractility, leading to nuclear shrinkage in cells. In red blood cells from sickle cell anemia (SCA) patients, Yoda 1 increases intracellular Ca2+ and phosphatidylserine exposure, which leads to KCa3.1 channel mediated Ca2+ influx and K+ and water efflux, causing shrinkage of the cells.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-160778 |
| Réf. fabricant | 18756756 |
| Nom chimique ou matériau | 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine |
| CAS | 448947-81-7 |
| Quantité | 50 mg |
| Cible | Other Calcium Channel Activators |
| Formule moléculaire | C<sub>13</sub>H<sub>8</sub>Cl<sub>2</sub>N<sub>4</sub>S<sub>2</sub> |
| Poids de la formule | 355.27 |
| Pureté | >99% |
