"/> Tocris Bioscience™ SJ 10542 | B-LABO France

Tocris Bioscience™ SJ 10542

Réf. : BL-RE-160786Réf. fabricant : 30000433 2 mg
431,95 € HT

Potent and selective JAK2/3 Degrader (PROTAC™)

Nom chimique ou matériau
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide
CAS
2789678-92-6
Quantité
2 mg
Cible
Active Degraders
Formule moléculaire
C41H46N12O5S
Marque
Tocris Bioscience

SJ 10542 is a potent and selective JAK2/3 Degrader (PROTAC™) (DC50 values are 11 nM and 14 nM for JAK3 and JAK2, respectively), it uses a phenyl glutarimide (PG) ligand as the cereblon (CRBN) recruiter. SJ 10542 displays high selectivity over GSPT1 and other members of the JAK family. SJ 10542 is active in cytotoxicity assays with PDX models (IC50 values <120 nM).

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-160786
Réf. fabricant30000433
Nom chimique ou matériau4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide
CAS2789678-92-6
Quantité2 mg
CibleActive Degraders
Formule moléculaireC<sub>41</sub>H<sub>46</sub>N<sub>12</sub>O<sub>5</sub>S
Pureté97%
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